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Cancer SAQs - Coggle Diagram
Cancer SAQs
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miRNAs
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Mutations
miR-34 overexpression inhibits bcl-2, which is pro-apoptotic, but this locus is often deleted in cancer
If they prevent translation of tumour suppressor genes, they can act as an oncogene, known as an oncomir.
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Mutated by amplification, deletion or epigenetic change
Leukemia
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Chronic Myeloid Leukemia
(This can be treated with Imatinib - which selectively inhibits ABL tyrosine kinase domain of BCR-ABL).
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Causes fusion of ALB kinase and BCR
BCR-ABL fusion protein
increased ABL protein activation causing an overactive tyrosine kinase
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Actute Myeloid Leukemia
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Rare :
Reciprocal translocation between promyelocytic leukaemia protein gene on CHR15 and Vitamin A R-alpha gene on CHR17.
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