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Inflammation SAQs - Coggle Diagram
Inflammation SAQs
NF-kB
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Location
viruses,
MHC1,
cell adhesion molecules
cytokines
Activation pathway
IKBa is phosphorylated and ubiquitinated, which tags IKBa for degradation by the proteasome
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Causes gene expression of select genes
mRNA leaves the nucleus and codes for chemokine, cytokines, apoptosis regulators, GFs and immune receptors.
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PAMPS and DAMP and PRRs
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Inflammasome
Formation
Assembly of NLRs, ASC (inflammasome adaptor) and pro-caspase
Function
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- Activation of inflammatory cells death
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Large cytosolic multiprotein complexes that assemble in response to detection of infection- or stress-associated stimuli and lead to the activation of caspase-1-mediated inflammatory responses, including cleavage and unconventional secretion of the leaderless proinflammatory cytokines IL-1β and IL-18
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Chemokines
Definition
Chemokines are proteins that mediate non-contact communication between cells, in the local tissue environment
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Pathway
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They activate their target cells, to cause activation of integrins on the cell surface
Adverse Effects
Inflammatory skin diseases,
Atopic dermatitis & psoriasis.
They attract neutrophils/ T cells, resulting in formation of a lesion
Atherosclerosis
chemokines on the endothelium are responsible for the adhesion of monocytes, which migrate into the tissue and transform into macrophages
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