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ANALYSIS - Coggle Diagram

- - - - identify region that unstructured
      - results include both sequence feature and alignment rows
    - - click on annotation row label - highlight the sequence, double click - select the sequence
  - - - estimate likely region of the disorders
        
        long disorder
        
        context-independent
        
        use 100 residue window
        
        above 0.5 = intrinsically disordered
        
        short disorder
        
        context-dependent
        
        se 25 residue window
        
        above 0.5 = short range disordered
        
        structured domain
        
        highlight likely global domain that useful for genomic structure investigation
    - - define region of globularity/ natively unstructured regions based on running sum of the propensity of residues to be structured or unstructured
- - - - Aligning nucleic acid sequences
    - - Uses the standard codon translation table to translate nucleotide alignment / selected region into a set of aligned peptide sequences
    - - European Nucleotide Archive (ENA) contains the record of the world's nucleotide sequencing information which includes raw sequencing data, sequence assembly information and functional annotation
      - Use for retrieval of protein or DNA cross references
      - Use for retrieval of protein features on coding regions