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Degenerative Medicine ( Muscular Dystrophy, Alzheimer's and
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Degenerative Medicine ( Muscular Dystrophy, Alzheimer's and
Rheumatoid Arthritis)
Muscular Dystrophy
Definition
Group of muscle diseases that results in increased weakening and breakdown of skeletal muscle over time
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Symptoms
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Instability :fallen_leaf:
Frequent falls
Poor balance
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Alzheimer's Disease
Definition
Irreversible, progressive brain disease that destroys memory and cognitive skills
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Genetics
Appoprotein E mutation
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What Apoity, you have alzheimer's at 19 years old !
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Amyloid Plaque Formation
- Amyloid is a membrane spanning protein
- Cleaved by:
Enzyme B secretase
Alpha secretase
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- Cleavage to monormer - insoluble
Clumps together to form amyloid plaques
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Tau Protein Hypothesis
- Internal neuronal structure support consists of microtubules
Tau protein stabilises microtubules
- Tau becomes hyperphosphorylated, causing microtubule collapse
- Tau proteins clumb to form neurofibrillary tangles
Leadsa to cell death and impaired synaptic transmission
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Inflammatory component
- Beta amyloid induced neuronal cell death is recognised by microglial
- Activation of microglia produces pro-inflammatory cytokines
IL-1
- Increased cell death
Increased processing of APP
More beta amyloid
More neuroinflammation
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