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Projects - Coggle Diagram

- - - - What scale and purity is sufficient ?
    - - Compare Kinetics, estimate what kinetic scales can be accessed per scheme
      - is there use here for titration of the HAT inhibitors ?
  - - - REMY crosstalk observation follow ups
- - - - random mutagenesis, library screening for novel writing patterns
        
        H3K4ac or H3K9ac in REMY (increasing catalytic activity here)
        
        single site acetylators
        
        epigenomic editors in vivo:
        DBD -- HAT domain fusions
      - domain walking
        
        which domains/combos from which families of HATs control writing specificity
    - - challenge against the various HAT inhibitors we have in lab
- - - - pAW4 == Trp vector with p300 - V5 proxy + pAW16_HDAC1 == Leu vector with HDAC1- streptagII proxy