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Azo-BphPs - Coggle Diagram
Azo-BphPs
BphP Conformational Model
"Zipper-like"
BphP
DrPCM
DrFull-Length (DrFL)
Positions
DrFL:
check distances in PHY-OPM helix
DrPCM
: maybe even in GAF-PHY helix works
"PHY tongue"
BphP
RePCM
DrPCM
Positions
"inside helix/sheet"
"in unstructured residues"
"one in tongue, one in GAF, facing each other"
"C-shaped"
BphP:
XccBphP
Position:
check distance to get 90° helix bend
"Rotational"
Positions:
check OPM distances
BphP:
IsPadC
Experiments
Spectroscopy
Wt + Azo "baseline"
1C-mut -/+ azo
1Cmut-cleanCs -/+ azo
other interesting mutations... (e.g. Y263W)
CD for conformational control
PHY tongue MD
Full-on structural stuff!
Crazy Ideas for later
"Digested Helix"
"Frankenstein" BphPs
Relay "stoppers"
Azo Dye
choose length
choose WL