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Male Hormonal Drugs, Increase protein anabolism and decrease protein…
Male Hormonal Drugs
:CONTRAINDICATIONS AND CAUTIONS
Contraindications and Cautions
The following are contraindications and cautions for the use of androgens:
Allergy to androgens or other ingredients in the drug. Prevent hypersensitivity reactions.
Pregnancy, lactation. Potential adverse effects on the neonate. It is not clear whether androgens enter breast milk.
Presence of prostate or breast cancer in men. Aggravated by the testosterone effects of the drug.
Liver dysfunction, CV disease. Can be exacerbated by the effects of the hormones.
Topical forms of testosterone have a Black Box Warning alerting user to the risk of virilization in children who come in contact with the drug from touching the clothes and skin of the man using the drug.
Danazol has Black Box warning regarding the risk of thromboembolic events, fetal abnormalities, hepatitis, and intracranial hypertension.
ADVERSE EFFECTS
Adverse Effects
Use of androgens may result to these adverse effects:
Androgenic effects: acne, edema, hirsutism (increased hair distribution), deepening of the voice, oily skin and hair, weight gain, decrease in breast size, and testicular atrophy.
Antiestrogen effects: flushing, sweating, vaginitis, nervousness, and emotional lability.
Common effects: headache (possibly related to fluid and electrolyte changes), dizziness, sleep disorders and fatigue, rash, and altered serum electrolytes.
A potentially life-threatening effect that has been documented is hepatocellular cancer
Increase the production of red blood cells.
Therapeutic Action
The desired and beneficial actions of androgens are as follows:
Growth and development of male sex organs and the maintenance of secondary male sex characteristics.
Increase the retention of nitrogen, sodium, potassium, and phosphorus and decrease the urinary excretion of calcium.
INTERACTIONS
Interactions
The following are drug-laboratory interactions involved in the use of androgens:
Decreased thyroid function
Increased creatinine and creatinine clearance (results that are not associated with disease states)
These effects can last up to 2 weeks after therapy has been discontinued
INDICATIONS:
Indications
Androgens are indicated for the following medical conditions:
Danazol is used for treatment of endometriosis, fibrocystic breast disease, and hereditary angioedema. It does this by inhibiting the hypothalamic-pituitary-adrenal (HPA) and gonadotropin-releasing hormones (GnRH), leading to a drop in follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Name and Definition
Androgens are male sex hormones, which include testosterone (produced in the testes) and androgens (produced in the adrenal glands).
*It is taken by oral route
Testosterone (Duratest, Testoderm) is the primary natural androgen and is the classic androgen used today. It is used for treatment of certain breast cancers and hypogonadism, a condition where there is undeveloped testis. All testosterones are class III controlled substances.
It kust he stored at the cool area, room temperature and away from light, excess heat and moisture.
Increase protein anabolism and decrease protein catabolism.
:STORAGE