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Lipids and Cholesterol - Coggle Diagram
Lipids and Cholesterol
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Statins
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MOA (3)
- Competetively antagonises HMG-CoA reductase enzyme
Decreases hepatic Cholesterol synthesis
- Activates Sterol Regulatory Element-Binding Protein (SREBP)
Transcription factor that bin to sterol regulatory element (SRE) DNA sequence
Upregulates hepatic LDL receptor increasing LDL clearance
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Statin Steampunk
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Treatment
- Hyperlipidaemia
- Prevention of arterial disease
- Secondary prevention of MI and stroke in Atherosclerotic disease
Fibrates
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MOA
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- Increase apo-A1
Increases HDL in plasma
- Increases Lipoprotein lipase activity
Reduces VLDL and plasma TG (decreasing LDL)
- Increases FFA uptake by liver and muscle
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Adverse Effects
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- Myopathy (don't combine with statins)
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Bempedoic Acid
MOA
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Inhibits cholesterol biosynthesis by inhibiting ATP-citrate lyase in hepatocytes
Upstream of statin target HMG-CoA reductase
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Apo B Inhibitors
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MOA
- Targets mRNA encoding of Apo B, reducing synthesis
- Inhibition of the assembly of VLDL
- Decreased LDL in the bloostream
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