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ADROGENS, STORAGE:, Androgens are male sex hormones, which include…
ADROGENS
Implementation:
Implementation with Rationale
These are vital nursing interventions done in patients who are taking androgens:
Monitor responses carefully when beginning therapy so that the dose can be adjusted accordingly.
Remove an old dermal system before applying a new system to clean, dry, and intact skin to ensure accurate administration and decrease risk of toxicity.
Monitor liver function periodically with long-term therapy and arrange to discontinue the drug at any sign of hepatic dysfunction.
Provide thorough patient teaching (e.g. measures to avoid adverse effects, warning signs, need for regular evaluation, especially blood pressure, etc.) to enhance patient knowledge about drug therapy and to promote compliance with the drug regimen.
Provide safety measures (e.g. adequate lighting, raised side rails, etc.) to prevent injuries.
Evaluation
CONTRAINDICATIONS AND CAUTIONS:
The following are contraindications and cautions for the use of androgens:
Allergy to androgens or other ingredients in the drug. Prevent hypersensitivity reactions.
Pregnancy, lactation. Potential adverse effects on the neonate. It is not clear whether androgens enter breast milk.
Presence of prostate or breast cancer in men. Aggravated by the testosterone effects of the drug.
Liver dysfunction, CV disease. Can be exacerbated by the effects of the hormones.
Topical forms of testosterone have a Black Box Warning alerting user to the risk of virilization in children who come in contact with the drug from touching the clothes and skin of the man using the drug.
Danazol has Black Box warning regarding the risk of thromboembolic events, fetal abnormalities, hepatitis, and intracranial hypertension.
ADVERSE EFFECTS:
Use of androgens may result to these adverse effects:
Androgenic effects: acne, edema, hirsutism (increased hair distribution), deepening of the voice, oily skin and hair, weight gain, decrease in breast size, and testicular atrophy.
Antiestrogen effects: flushing, sweating, vaginitis, nervousness, and emotional lability.
Common effects: headache (possibly related to fluid and electrolyte changes), dizziness, sleep disorders and fatigue, rash, and altered serum electrolytes.
A potentially life-threatening effect that has been documented is hepatocellular cancer.
THERAPEUTIC ACTIONS:
Therapeutic Action
Growth and development of male sex organs and the maintenance of secondary male sex characteristics.
Increase the retention of nitrogen, sodium, potassium, and phosphorus and decrease the urinary excretion of calcium.
Increase protein anabolism and decrease protein catabolism.
Increase the production of red blood cells.
INDICATIONS:
Androgens are indicated for the following medical conditions:
Danazol: Is used for treatment of endometriosis, fibrocystic breast disease, and hereditary angioedema. It does this by inhibiting the hypothalamic-pituitary-adrenal (HPA) and gonadotropin-releasing hormones (GnRH), leading to a drop in follicle-stimulating hormone (FSH) and luteinizing hormone
PHARMACOKINETICS
T1/2: 10-100 min
Metabolism: liver
Excretion: kidney (urine) and intestines (feces)
Storage Of Drug:
STORAGE:
Androgens are male sex hormones, which include testosterone (produced in the testes). It is an oral drug.
Repeated freezing and thawing of plasma or storage at various temperatures have only small effect. The Storage of 20°C to 25°C. Also protect them from light.