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Adrenergics - Coggle Diagram

- - - - Mixed alpha / beta blocker
        Treats hypertension in pregnancy
        IV hypertensive emergancy
- - - - Gq
        Vasocontrictive
        Smooth muscle constriction
      - Activation
        
        Arterial constriction - ↑ TPR
        Venous constriction -
        ↑MAP
        Mydriasis
        Urinary retention
    - - Gi
        Presynaptic autoinhibitory
      - Activation
        
        Gi decrease in cAMP
        Presynaptic autoinhibitory
        Decreases insulin secretion
        Decreases lipolysis
        Decreases aqueous humour production
  - - - Gs
        Cardiac
      - Activation
        
        ↑ cAMP and CA2+
        ↑ HR and contractility
        ↑ CO
        Renin release
    - - Gs
        Smooth muscle relaxation
      - Activation
        
        Bronchodilation
        Vasodilation
        Lipolysis
        Gluconeogensis
        Insulin secretion + hypokalaemia
        Aqueous humour production
    - - Gs
        Bladder relaxation
        Lipogenesis
- - - - Flannel
        Nasal decongestion
        Mydriasis
        Pressor effects ↑MAP
        Reflex bradycardia due to ↑MAP
    - - ↑ HR, Contractility, CO
        Vasodilation (b2 action)
        Treat heart failure + cardiogenic shock
    - - Alpha agonist, some beta activation
        ↑MAP
        Reflex bradycardia
        Increased cardiac contractility (b1 activation)
        
        Treats septic shock