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Cholinergics, Pralidoxime - Coggle Diagram

- - - - Gq
    - - Gi
      - Atria
        AV and SA
    - - Gq
      - NO release
        Increased cGMP
        Vasodilation
- - - - Physostigmine
        
        Atropine antidote
        Central CNS ffects
        
        Reverses central and peripheral atropine effects
      - Neostigmine
        
        Treats myasthenia gravis
      - Donezepil
        
        Done the brain puzzle
        Treats alzheimers
        Penetrates CNS
    - - Dyflos
      - Sarin
  - - - Contracts ciliary muscle, outflow of aqueous humour
        Activates sphincter pupillae to cause pupillary constriction
        Increases saliva
      - M3 selective
- - - - Belladonna
        Atropine Alice
      - Treats Organophosphate poisoning
      - Treats heart block and bradycardia
    - - Pirenzepine
    - - Methoctramine
    - - Darifenacin
      - Cevimlene
      - Hot as a hare
        Blind as a bat
        Dry as a cracker
        Mad as a hatter
  - - - Nicotine
      - Hexamethonium
      - Mecamylamine
      - Varenicline (partial agonists)
    - - Tubocurarine
      - Suxamethonium (agonist, depolarising blocker)
        
        Depolarising NMJ blocker
      - Curare
        
        Non-depolarising
      - Vecuronium
  - - - Choline acetyl transferase
    - - Choline transporter
    - - Release mechanism
    - - ACh vesicular transporter