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Thrombosis, platelet - Coggle Diagram

- - - - fibrinolytic
  - - - bridge
      - retracts
  - - - infarction,
        
        ischemic necrosis
      - pyemic abscesses.
- - - - turbulence
        
        aneurysms & vessel bifurcation
      - injury
        
        atherosclerotic plaque
    - - occluding
      - mural
    - - infract
    - - coronary
      - cerebral
      - femoral
  - - - DVT
        
        .deep in calf
        
        femoral
        
        popliteal
        
        iliac
      - phlebothrombosis
        
        occluding + propagates
        
        red or stasis thrombi.
      - thrombophlebitis
        
        draining septic
  - - - left ventricle
        
        Mural
    - - left atrium
  - - - pale thrombi
  - - - diffuse circulatory insufficiency,
- - - - granulation tissue or fibrosis
  - - - Red
        
        platelets and fibrin +++RBCs
      - Pale
        
        platelets and fibrin +RBCs
      - Lines of Zahn
        
        pale+ red
        
        aorta
        
        heart
    - - Mural
        
        non-occlusive
        
        adherent
      - Occlusive
        
        obstructs
      - Propagating
        
        obstructs
        
        tail
        
        new thrombus
- - - - :large_blue_circle:Stasis
        
        causes:
        
        Local
        
        Pressure
        
        Lack of muscular pumping
        
        valvular incompetence
        
        Systemic
        
        congestive heart failure.
        
        vein
      - :red_circle:Turbulence
        
        causes
        
        arterial aneurysm
        
        Myocardial aneurysm
        
        artery
      - effects
        
        Endothelial injury or dysfunction
        
        platelets :handshake:endothelium.
    - - causes
        
        Veins
        
        Mechanical trauma:
        
        Chemical injury
        
        Inflammation
        
        Endocardial
        
        Myocardial infarction
        
        Endocarditis
        
        Arteries
        
        hypertension
        
        free radicals
        
        Immune-induced arteritis
        
        radiation
        
        atherosclerosis
      - Effects
        
        Collagen
        
        Activation of |
        Hagman factor (XII)
        
        :check:Intrinsic coagulation
        
        Platelet Adhesion
        
        Secretion
        
        Von Willebrand factor
        
        thromboplastin
        
        :check: extrinsic coagulation
    - - 1 ry=genetic
        
        deficiency
        
        antithrombin III
        
        protein “C”
      - 2ry=acquired
        
        severe dehydration
        
        Postoperative
        postpartum
        
        contraceptives
        
        Tissue damage
        
        tumors
        
        2 more items...
        
        :arrow_upper_right:thromboplastin
        
        :arrow_upper_right:estrogen
        
        :arrow_upper_right:coagulation factors
        
        :arrow_lower_right:antithrombin |||
        
        :arrow_upper_right:platelet
        
        :arrow_upper_right:viscosity
      - most in capillaries and veins
- - - - platelet adhere
        
        platelet activate
        
        ADP
        
        primary hemostatic plug
        
        phospholipid
        
        intrinsic coagulation pathway
        
        thromboxane A2
        
        thrombin
        
        definitive secondary plug
        
        fibrinogen
        
        fibrin
        
        platelet or pale thrombus
        
        entangle WBC +RBC
        
        1 more item...
        
        occludes lumen
        
        "occluding thrombus”.
        
        next vessel
        
        to :<3:
        
        1 more item...
        
        contraction
        
        1 more item...
    - - exntrinsic coagulation pathway