CAR T cells challenges
Suppressive TME
Trafficking and infiltration
Antigen heterogeneity
T cell exhaustion
Target selection
Immune interviene
Cellular matrix
Metabolic changes
Anaerobic metabolism
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ROS overproduction
M2 macrophage
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Cancer associated fibroblasts
T regs
Checkpoint inhibitors
BBB
selective transport
Perispinal route
fUS (physical destr)
engineered scFv
transcript factor like activation
SNIP cars
Mono
Dual selection ( Math modelling)
TAA
Microenvironment
neo antigen
normal overexpression
abnormal expression
Immune system
BBB
Lymphatic drainage
APC
APC via MHC expression
Escape
natural heterogeneity
low adhesion low immune surveliance
Naive T cells are absent
APC and T cel interaction
glial lyphatic drainage
Intercellular fluid
CSF
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How activated immune cells transmigrate ?
Receptor downregulation
PD 1 downregulation strategies