Please enable JavaScript.
Coggle requires JavaScript to display documents.
CAR T cells challenges - Coggle Diagram
CAR T cells challenges
Suppressive TME
Immune interviene
T regs
Checkpoint inhibitors
Cellular matrix
M2 macrophage
Cancer associated fibroblasts
Metabolic changes
Anaerobic metabolism
ROS overproduction
Trafficking and infiltration
BBB
selective transport
Perispinal route
fUS (physical destr)
Antigen heterogeneity
Escape
natural heterogeneity
T cell exhaustion
engineered scFv
transcript factor like activation
SNIP cars
Target selection
Mono
TAA
neo antigen
normal overexpression
abnormal expression
Microenvironment
Dual selection ( Math modelling)
Immune system
BBB
low adhesion low immune surveliance
Naive T cells are absent
Lymphatic drainage
APC and T cel interaction
glial lyphatic drainage
Intercellular fluid
CSF
APC
APC via MHC expression
How activated immune cells transmigrate ?
Receptor downregulation
PD 1 downregulation strategies