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Zidovudine - Coggle Diagram
Zidovudine
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Mechanism of action
Zidovudine is an important used for treatment of HIV infection. It belongs to the family of nucleoside analogue reverse transcriptase inhibitors.
It is structurally related to the endogenous nucleoside thymidine with an azido group in place of the hydroxyl group at the 3 position of the deoxyribose ring.
Presence of azido group prevents formation of phosphodiester linkages needed for DNA replication causing chain termination.
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Indications
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It lowers the chances of getting complications HIV, cancer, infections like herpes zoster
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