OLANZAPINE Blockade of (D2, 5-HT2, α1, α2) as well as Muscarinic and H1 receptors. Both positive and negative symptoms of schizophrenia are improved. Broad spectrum - Schizo-affective disorders; approved for use in Mania. A/E: dry mouth, constipation, Weaker D2 blockade - ↓EPS, little rise in prolactin levels, more epileptogenic. weight gain , ↑risk of impairing glucose tolerance, ↑serum triglyceride. ↑risk of stroke in elderly