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Acute Inflammation - Coggle Diagram

- - - - Mast cells
    - - ↑ Vasodilation
        ↑ Vascular permeability
        ↑ Smooth muscle contraction
  - - - ↑ Vasodilation
        ↑ Vacular permeability
        ↑ Pain
  - - - ↑ Vascular permeability
        ↑ Chemotaxis
        ↑ Smooth muscle contraction
  - - - TNF-α
        IL-1
        IL-6
        IL-8
        Interferons
      - Function
        
        ↑ Immune cell recruitment and activation
  - - - ↑ Migration of immune cells
        ↑ Activation of immune cells
  - - - ↑ Phagocytosis
        ↑ Opsonisation
        ↑ Chemotaxis
        ↑ Mast cell degranulation
        ↑ Vasodilation
  - - - Activate immune cells
    - - Tissue damage
        Initiate self-perpetuating cyle of inflammation
  - - - Macrophages
        Enothelial cells
    - - ↑ Vasodilation
        ↑ Vascular permeability
        Regulates immune cell function
  - - - Serine proteases
        Matrix metalloproteinases (MMPs)
    - - Degrade ECM components
        ↑ Cell migration
        Regulate inflammation resolution
        Activate clotting cascade
- - - - Through vessel wall & alongchemotactic gradient to site of injury
    - - Fluid escapes vessels through gap junctions
        Vessel has high affinity for Histamine
    - - Polymorphs line endothelial wall, roll and adhere
        Transmigrate into tissues
        Binding of L, E, P selectins to their lignads
        Integrins activated. PECAM-1 on endothelium facilitates transmigration
    - - Exudation of protein-rich oedema fluid
        Dilutes toxins, allows Ig to opsonise, provides substrate for fibrin scaffold
  - - - Release of chemical signals : Histamine
    - - Migration of phagocytes to the site
    - - Macrophages and neutrophils consume bacteria and cell debris
- - - - Eosinophils
        Neutrophils
        Basophils
        Mast cells
    - - Monocytes
        
        Macrophage
        
        Dentricic cells
      - Lymphocytes