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Drug Overdose - Coggle Diagram
Drug Overdose
Paracetemol OD
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Timeline
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Stage1 : No symptoms in 1st 24 hrs
Mild nausea and vomiting
Stage2: 24-48 hrs
Increase in liver enzymes, INR
Stage3: 3-4 days - Complications (below)
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MOA
- NAPQI - toxic metabolite of Paracetomol
- Usually conjugated to Glutathione and excreted
- In OD a larger dose of paracetamol converted to NAPQI, and glutathione depletes, leading to build up
- NAPQI attacks nucleophilic thiol groups causing mitochondrial damage and necrotic cell death
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Opiates OD
Symptoms
Classic Triad
Pinpoint pupils :eight_pointed_black_star:
Respiratory depression :arrow_down::wind_blowing_face:
Coma :sleeping:
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Amphetamines, Cocaine, Ecstasy OD
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