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Diabetes - Coggle Diagram
Diabetes
Insulin Secretion
Basal, and meal stimulated
- Glucose uptake into pancreatic β cell through GLUT2
- Glucose metabolised to ATP
- ATP inhibits ATP sensitive K+ channel, decreasing K+ conductance (efflux??)
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- Opening of Ca2 channel, Ca2+ influx
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- Ca2+ causes exocytosis of insulin from storage vesicles
Drugs
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Biguanides
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Stimulates AMPK
Inhibits gluconeogenesis
Decrease intestinal glucose absorption
Increase glucose uptake
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Insulin Receptor
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Activation
- Binding of Insulin to α subunit
- Autophosphorylation of receptor
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- Results in Mitogenesis, protein synthesis, glycogen synthesis, glucose transport
- Translocation of GLUT4 receptors to cell surface
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Diabetes Mellitus
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Types
T1 Insulin dependant
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Symptoms
Polyuria, polydipsia, polyphagia
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