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Altered Hormonal & Metabolic Function - Coggle Diagram
Altered Hormonal & Metabolic Function
Damage to Hypothalamic-Pituitary Axis
Clinical Manifestations
Degeneration
Hypoxia
Tumors
Hemorrhage
Inflammation
Genetic defects
Infection
Function
Hypopituitarism: Decreased secretion of one or more pituitary hormones
Hyperpituitarism: excess of pituitary hormone secretion
Panhypopituitarism: decrease in pituitary hormones
problem with Pituitary secretes: ACTH, TSH, GH, FSH, LH, prolactin
Damage to Endocrine Glands
Function
Hyperplasia and excessive amount of horomone production and secretion
Mix: appropriately functioning but hormone lack biologic activity to elicit the cellular response.
Hypo: incapable of adequately responding to neuroendocrine messages and horome secretion is depressed or abset.
problem with target tissue function
Clinical Manifestations
infection
inflammation
atrophy
autoimmune conditions
radiation
Degeneration
Genetic defects
certain medications
Damage to Cell Receptors
Function
Intracellular inadequate often involve impaired enzyme or protein production or usage within the cell.
impaired recepor binding is manifested through circulating levels of hormones that are incapable of elicitg an appropirate response.
problem with receptor binding and cell-to-cell communication to elicit a cellular response.
Clinical Manifestations
Decreased number of receptors
Lack of receptor sensitivity to the hormone
Presence of antibodies that block receptor sites
Presence of antibodies that occuy the receptor site and mimic the hormone
Presence of tumor cells with receptor acitivity that deprives the unaffected cells of the hormone.
Damage to Feedback Mechanisms
Clinical Manifestation
Ectopically production
Neoplasms/tumors
Function
problem: Failure to response to hormone levels and continue to suppress or stimulate hormone production and secretion.
Treatment
Tumor Removal
Diagnositc
CT
MRI
General Manifestations of Altered Hormone Function
Clinical Manifestation
Fatigure
Weakness
Anorexia
Sexual dysfunction
Growth impairment
Dry skin
Constipation
Cold intolerance
Function
Hyperpituitarism: excess of one or more pituitary hormones
Hypopiuitarism: deficit of one or more pituitary hormones
Damage to Metabolism and Elimination Mechanism
Clinical Manifestation
Liver disease
Kidney disease
Function
Problem: inactivation of metabolism and elmination. Resulting in excess circulating hormone
Treatment
Low hormone levels: medication for lifelong replacement
Excessive hormone: medication to block effects of the hormone
Diagnostic
24 hours urine analysis
Blood work and urine analysis
Physical exam
Complete pt history