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cell injury 3, image, image, image, image, image, image, image, image,…

- - - - too severe injury
    - - nucleus
        
        karyorrhexis
        
        fragmented
        
        pyknosis
        
        shrunken basophilic
        
        karyolysis
        
        disappears
      - cytoplasm
        
        eosinophilia
        
        :no_entry: RNA / ptn
        
        glassy
        
        :no_entry:glycogen
        
        vacuolization
        
        no boundaries
        
        rupture
        
        dystrophic calcification
    - - coagulative
        
        mech
        
        denaturation of proteolysis enzymes
        
        digestion of dead cell
        
        autolysis
        
        heterolysis
        
        site
        
        solid organs
        
        ischemia
        
        liver
        
        virus / toxic
        
        skin
        
        burns :fire:
        
        ischemic infarct
        
        except brain
        
        morphology
        
        grossly
        
        opaque
        
        triangle
        
        firm and raised
        
        2 more items...
        
        apex to closed vessel
        
        microscopic
        
        cyto
        
        eosinophilic
        
        preserved outline
        
        1 more item...
        
        nucleus
        
        karyolysis
        
        pyknosis
        
        1 more item...
        
        cause
        
        anoxia
      - liquefactive
        
        causes
        
        autolysis
        
        brain and spinal cord ischemia
        
        heterolysis
        
        pus formation
        
        morphology
        
        grossly
        
        soft
        
        semiliquid
        
        cyst wall
        
        microscopic
        
        cyst space
        
        cell debris
        
        filled macrophage
        
        cyst wall
        
        capillaries
        
        inflammatory cells
        
        1 more item...
      - caseous :cheese_wedge:
        
        causes
        
        histotoxic of lipopolysaccharide
        
        tubercle bacilli
        
        mycobacterium tuberculosis
        
        morphology
        
        grossly
        
        dry cheese
        
        soft
        
        granular
        
        1 more item...
        
        microscopic
        
        center
        
        esinophilic
        
        granular debris of nuclei
        
        1 more item...
        
        surround
        
        granuloma
      - fat
        
        mechanism
        
        adipose tissue
        
        lipases
        
        FA
        
        Ca++
        
        1 more item...
        
        causes
        
        enzymatic
        
        acute hemorrhagic pancreatitis
        
        traumatic
        
        breast & subcutaneous
        
        inflammation reaction
        
        foreign giant cell
        
        morphology
        
        grossly
        
        gelatinous
        
        Ca chalky white
        
        micro
        
        outline
        
        basphilic Ca
        
        surrounded by inflamm cells
      - fibrinoid
        
        cause
        
        autoimmune diseases
        
        collagen
        
        denaturation
        
        fragmentation
        
        1 more item...
        
        PAN
        
        SLE
        
        rheumatoid
        
        typhoid fever
        
        striated muscle
        
        lose striations
        
        nuclei disappear
        
        1 more item...
        
        morphology
        
        micro
        
        firbin :arrow_forward: bright red
        
        amorphous mass :arrow_forward: eosinophilic
      - gangernous
      - gummatous
        
        cause
        
        3ry stage syphilis
        
        coagulative
        
        liquefactive
        
        more architecture preservation than caseous
    - - local
        
        loss of function
        
        hematuria
        
        arrhythemia / HF
        
        hemiplegia
        
        brain
        
        heart
        
        kidney
      - systemic
        
        fever
        
        leukocytosis
    - - heart
        
        hepatic bile duct
        
        hepatocyte
        
        transaminases
        
        alkaline phosphatase
        
        troponin
        
        creatine kinase
    - - small area
        
        removed by macrophage
        
        .
        
        regeneration
        
        fibrosis
        
        liquefied
        
        lymphatics
      - large area
        
        encapsulation
        
        dystrophic Ca++
      - complication
        
        putrefaction
        
        gangrene
        
        sepsis
        
        abscess
    - - opaque
      - pale
  - - - less severe injury
      - normal processes
    - - physiological
        
        embryogensis
        
        hormone dependent
        
        endometrial
        
        lactating breast
        
        cell deletion
        
        intestinal crypt
      - pathological
        
        tumor
        
        chemotherapeutic
        
        cytotoxic T cells
        
        graft-versus-host
        
        rejection
        
        CD4+T depletion
        
        AIDS
        
        viral infec
        
        viral hepatitis
        
        councilman bodies
        
        atrophy
        
        environmental
        
        DNA damage
        
        P53
        
        apoptosis
        
        repair
    - - mitochondrial intrinsic
        
        caspases
        
        endonuclease
        
        apoptotic body
        
        cytoskeleton breakdown
      - receptor extrinsic
    - - dying process
        
        cells
        
        shrunken
        
        eosinophilic
        
        round to oval
        
        organelles
        
        shrunken / normal
        
        nucleus
        
        pyknosis
        
        blebs
        
        apoptotic bodies
        
        no inflammation
      - elimination
        
        phagocytosis