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Leukemia - Coggle Diagram

- - - - Subtypes with specific chromosomal translocations or gene mutations
    - - AML is associated with microscopic features of dysplasia in at least 50% of cells in at least two lineages
    - - Mutations in the MLL gene and poor clinical response
    - - Absence of cytogenetic abnormalities
- - - - Subtypes are distinguished by morphology, immunophenotype
        and genetic analysis
  - - - The CLL tumor cell is a mature B cell with weak surface
        expression of immunoglobulin
        
        CLL cells typically exhibit impaired apoptosis and a prolonged lifespan, and this is reflected in their accumulation in the blood, bone marrow, liver, spleen and lymph nodes
        
        Small lymphocytic lymphoma is the tissue equivalent of CLL and lymphoma cells have the same immunophenotype and cytogenetics as CLL
- - - - 9:22 translocations or 12:21 translocations, MLL rearrangements included.
    - - NOTCH signalling pathway activated
  - - - Anemia
      - Neutropenia
      - Thrombocytopenia
    - - Tender bones
      - Lymphadenopathy
      - Splenomegaly
      - Hepatomegaly
      - Meningeal syndrome