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Lymphoma - Coggle Diagram

- - - - Fever
      - Pruritus
      - Alcohol-induced pain
      - Other constitutional such as weight loss, profuse sweating, weakness, fatigue, anorexia, and cachexia.
  - - - Stage I
        
        Node involvement in one lymph node area
      - Stage II
        
        Disease involving two or more lymph nodal areas in one side of the diaphragm
      - Stage III
        
        Disease involving lymph nodes
        above and below the diaphragm
      - Stage IV
        
        Involvement outside the lymph node areas and refers to diffuse or disseminated disease in the bone marrow, liver and other extranodal sites
- - - - They can be divided into those resembling precursor B cells found in the bone marrow, and those which resemble germinal centre cells or post-GC cells from lymph nodes.
  - - - High-grade
        
        Relatively indolent, respond well to chemotherapy
        but are very difficult to cure
      - Low-grade
        
        Aggressive and need urgent treatment but are more often
        curable.
- - - - BCL2 antagonizes apoptosis and promotes the survival of follicular lymphoma cells