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Healing & Repair , Healing/Repair: Restoration of tissue architecture…
Healing & Repair
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Outcomes of injury
Injury is too severe & overwhelms patient, who then dies
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AI fails to remove injured tissue, AI --> CI
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Stromal factors
Cells: fibroblasts, fibrocytes, chrondrocytes, osteocytes
ECM
Interstitial matrix
Between epithelial, endothelial & smooth muscle cells
Collagen (fibrillar & non-fibrillar, elastin
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Additional factors
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Intrinsic
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Mechanical factors
Increased pressure, torsion or excessive movement--> dehiscence
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Phases of Healing
1st intention healing
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Day 3 - macrophages replace neutrophils, invasion of granulation tissue & angiogenesis
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