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Healing & Repair , Healing/Repair: Restoration of tissue architecture…

- - - - Most epithelial cells & haematopoietic cells
    - - Mesenchymal cells, parenchymal cells
    - - Cardiac myocytes, neurons
      - Cells have left cell cycle - no regeneration = scar tissue
- - - - Cell surface adhesion molecules
      - Matrix adhesion molecules
- - - - Between epithelial, endothelial & smooth muscle cells
      - Collagen (fibrillar & non-fibrillar, elastin
    - - Produced by epithelial & mesenchymal cells
      - Non-fibrillar collagen (IV)
- - - - Labile, stabile, permanent (local)
    - - Diabetes
    - - Anti-inflammatory & immunosuppressive effects result in weak scar tissue
    - - Increased pressure, torsion or excessive movement--> dehiscence
    - - Extensive exudates in body cavities undergo organisation with eventual scarring > adhesions