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Neoplasia - Coggle Diagram
Neoplasia
Hallmarks of Cancer
All cancers display 8 fundemental changes in cell physiology which are concidered "hallamrks of cancer"
- Sustaining proliferative signalling
- Evading growth suppressors
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- Enabling replicative immortality
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- Activating invasion and metastasis
- Reprogramming of energy metabolism
- Evading immune destruction
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Spread
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Distant
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Spread through body cavity, lymphatics, blood vessels to reach distant sites
Invasion
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Process
- Cells adhere to and invade basement membrane
- Pass through ECM and intravasate into blood vessels / Lymphatics where they interact with lymphoid cells
- Clonal expansion, growth, diversification, angiogenesis
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- Adhesion to bascement membrane
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- Metastatic deposit, angiogenesis, growth
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Definition
Abnormal mass of tissue, whose growth exceeds and in uncoordinated with that or normal tissue, and persists in the same excessive manner even after conclusion of the stimuli which has evoked the change (tumour)
