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Cancer Genetics - Coggle Diagram
Cancer Genetics
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Oncogenes
- Wildtype proto-oncogenes
Proto-oncogenes often code cell proliferation promoting factors
- Oncogenes encode oncoproteins - often growth factor receptors
- Oncoproteins cause neoplastic transformation by interfering with normal cell growth / differentiation
- Oncoproteins bear mutations that inactive internal regulatory elements
- Oncoprotein activity not dependant on external signalling
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Tumour Suppressor Gene
Genes which by sustaining loss of function mutation, facilitate the development of cancer
Normally involved in growth suppression, or maintenance of DNA integrity
Mutations
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Qualitative mutation
Insertions, deletions, frameshift
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