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ADRENERGIC ANTAGONISTS - Coggle Diagram

- - - - Non-selective
        
        Blocks alpha 1 and 2 receptors
        
        Phentolamine & Phenoxybenzamine are used to treat hypertension caused by phechromocytoma.
        
        Causes an increase in norepinephrine release.
      - Selective alpha blockers
        
        Alpha 1 blockers
        
        Selectively and reversibly block alpha 1 Receptors in vascular smooth muscle
        
        Reduces peripheral resistance
        
        Blocks smooth muscle Receptors of the bladder neck and prostate gland
        
        Alfuzosin and Tamsulosin relieve urinary difficulties linked with enlarged prostate (BPH)
        
        Ends with osin
        
        Prazosin, Doxazosin, Terazosin are used to treat hypertension
        
        SIDE EFFECTS
        
        Orthostatic hypotension
        
        Headache and nasal congestion caused by vasodilation
        
        Alpha 2 blockers
        
        Very limited clinical application
        
        Yohimbine reverses sedative effects on veterinary medicine
- - - - Propanolol is used to treat migraines prophylaxis because it can penetrate the CNS
      - Sotalol and Timolol is applied tropical to the eye to treat glaucoma
      - Used to treat hypertension, heart failure, heart attack, agina and cardiac arrhythmia
      - Other examples include pindolol and nadolol
      - Adverse effects
        
        Causes decreased heartrate
        
        Decreased cardiac output
        
        Reduces contractility
        
        Brochoconstriction due to blocked b2 receptors
      - Caution: Not to be used on patients with COPP or asthma
    - - No clinical use mostly
      - Atenolol
      - Acebutolol
      - Bisopronol
      - Esmolol
      - Metoprolol
    - - A combination of both blockers
      - Also acts on blood vessels and causes vasodilation
      - Carvedilol and labetalol causes peripheral vasodilation
      - Nebivolol(B1 selective) causes vasodilation by inducing nitric oxide release
      - Betaxolol produces vasodilation by blocking calcium channels and treats glaucoma
      - Used to treat hypertension