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Mohamed’s Spleen, causes - Coggle Diagram

- - - - a type of blood cancer, arising from abnormal growth of myeloid progenitor cells in the bone marrow.
        
        pathophysiology
        
        Involves a genetic abnormality called the Philadelphia Chromosome. It results from a reciprocal translocation between chromosomes 9 and 22.
    - - Fatigue Weakness & Malaise
      - Abdominal discomfort or fullness
      - Easy bruising, bleeding, or petechiae
      - Infections
      - Unintentional weight loss
      - Night sweats and fever
      - useful in
    - - Medical history and physical examination
      - Blood tests
      - Bone marrow biopsy
        
        procedure
      - Imaging studies
    - - 1, Tyrosine Kinase Inhibitors
        
        Hematopoietic Stem Cell transplantation
        
        Palliative Therapy with cytotoxic agents
        
        why its done
        
        Post-Chemotherapy
        
        To Kill Cancer
        
        Non-functional Bone Marrow
        
        risk
        
        GvHD
        
        occurs when the donor stem cells that make up the new immune system see the body's tissues and organs as something foreign and attack them.
        
        used in some
  - - - Shock and disbelief
      - Fear and anxiety
      - Anger, guilt and blame
    - - loneliness
      - Relationships
      - work
- - - - diagnosis
        
        Physical examination- palpate the side and back of left hypochondriac region below the left costal margin. Splenomegaly (>2cm)
        
        Blood Tests- CBC and Liver function tests
        
        Ultrasound and CT- visualises the spleen and nearby tissues
        
        MRI- helps trace blood flow in the spleen
  - - - left upper quadrant of the abdomen, under the rib cage
    - - filtering blood by removing old or damaged cells and debris, as well as helping the body fight infections
- - - - types
        
        -Neutrophilia (the most common form)
        
        causes
        
        Bacterial infection
        
        -Acute inflammation
        
        -Some drugs such as steroids
        
        -Malignancy
        
        -Lymphocytosis
        
        causes
        
        Acute viral infections such as infectious mononucleosis, hepatitis
        
        -Chronic lymphocytic leukemia
        
        -Acute lymphoblastic leukemia
        
        -Lymphoma
        
        -Monocytosis
        
        causes
        
        -Malignancies
        
        -Autoimmune diseases
        
        -Chronic infections
        
        -Eosinophilia
        
        -Basophilia
        
        causes
        
        -Allergy or inflammation (Drug, food, inhalant hypersensitivity)
        
        -Infection (Chicken pox, Influenza, smallpox, Tuberculosis)