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Toxicology - Coggle Diagram
Toxicology
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Mechanism of Toxicity
- Inflammation and immune mediated
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- Altered enzyme and receptor function
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3.Organ directed damage
Acetaminophen, methanol, alcohol, cigarette smoke
- Human development - Teratogens
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Organophosphates
Mechanism of Toxicity
Altered enzyme function
- Serine residue of AChE phosphorylated and ages
- ROH group replaced by hydroxyl
- Stable and irreversible ageing (can be reversed if caught early enough)
Antidote
Pralidome
- Breaks bond between organophospate and serine
- Release of organophosphate and regeneration of serine hydroxyl group on AChE
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