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Obesity drugs - Coggle Diagram
Obesity drugs
Orlistat
Contraindications
• Organ transplant
• Liver disease
• Type 1 and 2 diabetes
• Kidney disease
• Gall bladder disease
• Thyroid disease
Side effects
• Pain in rectum
• Abdominal Pain
• Irregular menstrual cycle
• Difficult breathing and swallowing
• Severe fatigue
• Nausea and vomiting
• Loss of appetite
Indication
Long-term therapy is indicated for obese patients with a BMI of
30kg/m2 or greater and for patients with a BMI of 27kg/m2 who also have diabetes,dyslipidemia,orhypertension.
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Mechanism of action
Orlista is a nonsystemic inhibitor of gastrointestinal lipases that are necessary for the break down of fat in the GI tract.The unabsorbable fat is then excreted.Orlistatisa synthetic derivative of lipostatin isolated from as oil
bacterium,Streptomyces toxytricini.
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Subtramine
Indication
Long-termtherapy is indicated for obese patients with a BMI of
30kg/m2 or greater and for patients with a BMI of 27kg/m2 who
also have diabetes,dyslipidemia,orhypertension.
Side effects
• Dry mouth
• Upset stomach
• Changes in appetite
• Headache, back and joint pain
• Depression
• Dizziness
• Mild skin rash
• Insomnia
• Constipation
Contraindications
• Anorexia nervosa or bulimia nervosa
• Concomitant monoamine oxidase inhibitor use
• Concomitant use of centrally acting appetite suppressants
• Hypersensitivity to sibutramine
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Mechanism of action
Sibutramine is a non-amphetamine appetite suppressant that blocks the neuronal uptake of norepinephrine,serotonin,and dopamine.
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Phentermine
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Side effects
•Shortness of breathing
•Dizziness
•High blood pressure
•Itching,redness and rash
•Feeling faint
•Chest, jaws and arm pains
Indication
• short-term adjunct in a regimen of weight reduction based on
exercise,behavioral modification and caloric restriction in the
management of exogenous obesity.
• patients with an initial body mass index greater than or equal to 30kg/m2,or greater than or equal to 27kg/m2 in the presence of the risk factors,hypertension,diabetes,hyperlipindemial.
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Mechanism of action
reduceses body weight by
decreasing appetite,increasing the amount of energy used by body or by affecting certain parts of the brain.
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