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Immunopathology, Immunity: Protection from infectious pathogens, Innate…

- - - - Production of IgE
      - Lipid Mediators
        
        Leukotrienes: Vasoactive & spasmogenic agents
        
        Increase vascular permeability
        
        Bronchial smooth muscle contraction
        
        Chemotactic for neutrophils, eosinophils, monocytes
        
        Prostaglandin D2
        
        Platelet-activating factor (PAF)
      - Cytokines
        
        TNF
        
        IL-1
        
        Chemokines
    - - Production of IgG, IgM
      - Deposited Ab activate complement, generating by-products, including chemotactic agents
        
        C5a
        
        Direct migration of polymorphonuclear leukocytes and monocytes
        
        C3a and C5a
        
        Increase vascular permeability
    - - Phagocytosis & lysis of cells
    - - Perivascular cellular infiltrates
      - TH1 secretes cytokines, mainly IFN-y