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Molecular basis of Cancer - Coggle Diagram
Molecular basis of Cancer
Cancer cells
Benign tumour
Grow in a confined area
Does not cause injury/disease to remainder of the body
Malignant
Invade surrounding tissues
May enter the blood & lymphatic systems
Cause death if untreated
Paraneoplastic syndromes
Characteristics
Immortal
Disturbed differentiation
Loss of contact inhibition by surrounding cells
Invasive/metastatic
Major categories
Carcinoma
Malignant neoplasm of epithelial origin
Sarcoma
Originate in supportive & CT
Myeloma
Cancer originates in the plasma cells of bone marrow
Leukaemia
Cancer of blood cells
Lymphoma
Develop in glands & nodes of lymphatic system e.g. spleen, thymus
Apoptosis & mechanisms of activation
Multiple hit theory of carcingonesis
Drivers of cell growth - oncogenes & pathways they act in
Regulation of cell division
Tumours suppressors as gatekeepers & caretakers of the genome