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neonatal hypotonia - Coggle Diagram
neonatal hypotonia
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genetic examinations
targeted clinical phenotyping: cranial MRI,eye examination
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consider: kariotype/fluorescent in situ hybridisation; rapid chromosomal microarray, PWS, SMA, type 1 myotonic dystrophy - early
no molecular diagnosis: mitochondrial genome analysis, muscle biopsy, research genomic analysis, reanalysis of genomic data at 2-3 y intervals
primary
central: low muscle tone, normal/exaggerated deep tendon reflexes, relative preservation of antigravity movements
peripheral: hypotonia, profound weakness, absent/diminished deep tendon reflexes, absent neonatal reflexes
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secondary: infections, hypoglycemia, inborn errors of metabolism, HIE, encephalopathy