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factors affecting drug absorption and distribution - Coggle Diagram
factors affecting drug absorption and distribution
Main routes of administraion
Injections
Intra muscular (in muscle)
Inrathecal (around spinal cord)
Intra venous (in vein) 100%bioavailable
Subcutaneous (Under skin)
Others
Rectal
Sublingual
Topical
Inhalational
Oral
Drug passage across cell membrane
Lipid solubility
pH and ionization
concentration gradient
Molecular size
Difusion
Passive difusion
High to lower concentration
Carrier mediated OR pinocytosis
pinocytosis
Carrier- mediatet
Filtration
Such channels are plrntiful in gut mucosa and renal tubule and absent in blood brain barrier and placenta
Abstract
Pharmacokinetics
metabolism
absorption
excreation
Drug administration
distribution
Distribution of drugs in body
Volume of distribution and compartment models
Single comportment models
Multi compartment models
Distribution of drugs in fetus
Higher protein binding in fetus would increase drug transfer
In pre-eclampsia when maternal serum albumin levels are low now this increase transfer of neutral and acidic drugs
When pH of fetal blood is lower than mother so drug well more ionized across placenta...fetus becomes toxic/acidic
Body fluid compartents
