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Lisdexamfetamine ( Vynanse ) Vyvanse-1-300x200 - Coggle Diagram
Lisdexamfetamine ( Vynanse )
Mechanism of Action
Lisdexamfetamine is an inactive drug that is converted
In the body to dextroamphetamine
A pharmacologically active compound which is responsible for drugs activity
Lisdexamfetamine is broken down by enzymes in red blood cells to form l- lysine
The conversion of lisdexamfetamine to dextroamphetamine is not affected by gastrointestinal PH
The optical isomers of amphetamine eg Dextroamphetamine can enter monoamine neurons
This allows them to release monoamine neurotrasmitters
from these storage site in presynaptic neuron
Indications
Primary treatment for attention deficity hyperactivity disorders
Enhancing cognitive performance
Physical performance
Side effect
Decrease appetite
Insomnia
Dry mouth
Weight loss
Upper abdominal pain
Nausea and vomiting
Increase heart rate
Contraindications
Patients with hyperactivity to amphetamine products
To patients who have monoamine oxidase inhibitors within 14 days
Patients with history of drugs abuse and heart disease
Severe hypertension
Severe agitation
Storage
Store in close container at room temperature
Away from heat, moisture and direct sunlight
Route of administration
The lisdexamfetamine is administered orally
The capsule should be swallowed not crushed or chewed
