Please enable JavaScript.
Coggle requires JavaScript to display documents.
Physostigmine (Antilirium) W9397NK76E - Coggle Diagram
Physostigmine (Antilirium)
Mechanism of action
Physostigmine inhibits acetylcholinesterase enzyme responsible for breakdown of used acetylcholine
By interfering with metabolism of acetylcholine
Physostigmine indirect stimulate both nicotic and muscularin receptors
Due to consequential increase in available acetylcholine in synapse
Indications
Glaucoma
Severe anticholinergic toxicity
Slow gastric emptying
Contraindications
Use with caution in asthmatic patients
Epilepsy, diabetes,
Cardiovascular diseases
Discontinue use in excessive sweating & diarrhoea
Not recommended in patients with triyclic antidepressants intoxication
Side Effects
Increased sweating
Loss of bladder control
Muscle weakness
Nausea and vomiting
Stomach cramps & pain
Storage
Should be stored on controlled room temperature of between 20 -25 degree Celsius
Route of administration
Physostigmine usually administered as injection solutions, IMI or IV
