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Hypersensitivity Reactions - Coggle Diagram
Hypersensitivity Reactions
Type II
Cell-bound Ag + circulating Ab
Cytotoxic or Ab-mediated cellular dysfunction
Clinical eg.
Autoimmune haemolytic anemia
Goodpasture's syndrome
Transfusion reactions
Grave's disease
Type III
Circulating Ag-Ab complexes
Clinical Eg.
Immune complex disease: serum sickness
Post-streptococcal glomerulonephritis
Type IV
Clinical examples
TB
Contact dermatitis
Transplant rejection
Delayed-type cell-mediated
T cells release cytokines
Type I (anaphylaxis)
IgE (embedded in mast cells or basophils)
Mast cells release vasoactive substances
Degranulation: triggered by C3a and C5a
Preformed mediators: histamine, chemokines, proteases
Secondary mediators: prostaglandins, leukotrienes
Clinical
Systemic anaphylaxis
Local anaphylaxis
Asthma