Over the past few years, the importance of the microbiome in CRC has been increasingly emphasized, particularly in terms of how the gut microbiome can cause initial inflammation and affect various signaling pathways that promote carcinogenesis. Compared to a healthy gut microbiome, the microbiota in CRC patients consists of different strains of bacteria, including Bacteroides fragilis, Streptococcus gallolyticus, Enterococcus faecalis, Escherichia coli, Fusobacterium nucleatum, Parvimonas, Peptostreptococcus, Porphyromonas, and Prevotella, which have been linked to CRC development. (Rebersek, 2021).