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Selenium and immune function (Se Part 2 Advances) - Coggle Diagram

- - - - Moses et al 2008- women with pre-eclampsia associated with polymorphism (GA or AA genotype) than controls- A allele carries risk for pre-eclampsia
- - - - se lowers disease progression and eye involvement and improves QOL
    - - se reduces autoantibody levels
  - - - Zivang had higher Se compareed to Xi'an and Zivang had lower odds of hypothyroidism and autoimmun hypothyroidism and pathological thyroid conditions
      - Prospective cohort study- follow up found Se deficiency in 46% of people in Se adequate region and 89% in low-se region
        
        LOW SE CAUSES DEVELOPMENT OF HYPOTHYROIDISM and increaing se intake may reduce risk
    - - RCT- supplemented Se in autoimmune thyroiditis decreased inflammation and TPO autoantibody concentration, lower TPOAb levels 3-12 months later. Mixed evdience for 12 months
- - - - prospective cohort- cancer rhazard ratio of mortality redcued with increasing Se serum level until 130ug/L THEN increases after 150ug/L- varies depending on cancer type
  - - - signficiant reduction in cancer risk occurs on se supplementation of those with plsma se <105ug/l at baseline/ non-signficant if >122ug/l at baseline.