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Immunopathology - Coggle Diagram
Immunopathology
Immune Sensing and Signalling
Sensor: Pattern Recognition Receptors (PRRs)
Adaptor: Recruits/activates TF
Transcription Factors
Cytokine: Messenger and effector
Trigger phagocytosis, inflammatory gene transcription
Types of Immunopathologies
Immune deficiencies
Primary (genetic/inherited)
Defects in phagocyte numbers and/or function
Complement Deficiencies
Defects in cellular function: activation pathways, effector pathways, disrupted migration
T cell and B cell immunodeficiencies
Ab Deficiencies
Secondary (acquired)
Cancer, diabetes
Malnutrition
Chemotherapy
Infections
Overreactive: Hypersensitivities and allergies
Excessive activation of a normally beneficial immune response
4 major types
I - Immediate (Allergy)
1st step - Sensitisation
2nd step - Challenge (repeated exposure)
II - Antibody (Anemia)
III - Antibody - Antigen (Reactive Athritis)
IV - T cells (MS)
Self attacking: Autoimmune disease
Uncontrolled growth: Neoplasias
The Major Histocompatibility Complex (MHC)
Encodes MHC Class I & II
All nucleated cells express MHC Class I
Only Ag presenting cells (e.g. DC) express MHC Class II