Initially, the hormone must bind to the receptor on the target cell. Cell delivers responds to certain hormones and not to others because of existence specific hormone receptors, which are a type of protein. These protein receptors can be: part of the cell membrane or located in the cytoplasm or on the nucleus of the target cell. Hormones only will affect cells that have specific receptors. Hat cells, for example, only have Cell membrane receptors for insulin, glucagon, and growth hormone.