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Infective Endocarditis - Coggle Diagram

- - - - Rapid destruction of endocardial tissue
      - 35-40% of native valve cases
      - Typically affects healthy valves
      - Fatal within 6 wks
  - - - primarily in px with preexisting damage to heart valves, structural defects or prosthetic valves
      - 20% of native valve IE cases
        
        Most common cause of subacute
- - - - Rheumatic heart disease
      - Aortic stenosis
      - Degenerative alvular disease
- - - - Aherence of platelets + fibrin
        
        Sterile vegetation
  - - - Bacterial colonization of vegetation
        
        Formation of fibrin clots
        
        Valve destruction and loss of function
        
        Valve regurgitation
  - - - Aortic
      - Tricuspid
        
        Most common in persons who inject drugs
      - Mitral
      - Pulmonary
  - - - Bacterial thromboemboli
        
        Vessel occlusion
        
        Infarctions
    - - Metastatis infections of other organs
    - - Glomerulonephritis, osler nodes
- - - - Tricuspid
        
        Regurgitation
        
        Holocsystolic murmur
        
        In persons who inject drugs, immunocompromised individuals, px with congenital heart disease and px with instrumentation in the right heart
      - Aortic
        
        Early diastolic murmur
      - Mitral
        
        Holosystolic murmurH
  - - - Petechiae
      - Janeway lesions
      - Osler nodes
      - Roth spots
    - - Acute renal injury
      - Splenomegaly and LUQ pain
    - - Septic stroke
      - Seizures, paresis
      - Hemorrhage meningitis
      - Encephalitis
      - Abscess
  - - - Dyspnea
    - - Multifocal pneumonia