Please enable JavaScript.
Coggle requires JavaScript to display documents.
Antiepipleptics - Coggle Diagram
Antiepipleptics
Seizures
Types
Primary / Generalised
Focal
Sudden burst of uncontrolled electrical activity in the brain
Cause
Inbalance of excitatory or inhibitory processes
Drugs by MOA
Enhancement of GABA action
Phenobarbitone
GABA-A receptor +ve modulator
Benzodiazepines
Viagabatrin
Valproate
GABA Transaminase inhibition
Tigabine
Inhibits GAT1
Inhibition of Na+ channel function
Phenytoin
Carbamazepine
Lacosamide
Valproate
Inhibition of Ca2+ channel function
Gabapentin
P / Q type
Ethosuxamide
T type
Valproate
T type
Drugs by Seizure Treatment
Focal
Valproate
Gabapentin
Phenobarbitone
Ganaxolone
Tigabine
Lacosamide
Focal / Tonic-clonic
Phenytoin
Carbamazepine
Generalised
Ethosuxamide
MOA
GABA
Increase GABA release
Increase availlable GABA to activate GABA-A receptors
Increase Cl- influx - Hyperpolarisation
Decrease GABA reuptake / metabolism
Na+ channel blockers
Maintain inactive state
Lengthen refractory period
Ca2+ channel blockers
P/Q type Ca2+ channels
Decrease Glu release presynapticlly
T-type Ca2+ channels
Decrease excitation
Control synchronisation of thalamocortical neurons