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Parkinson's Disease, caused by degeneration of neurons in…
Parkinson's Disease
Neurological Damage
damage to neurons
formation of Lewy bodies
damage to neurites
Lewy Neurites
affects
dorsal motor nucleus of the vagal nerve
Cytoskeleton organization
cell death
alteration nigrostriatal circuit
Treatment
Deep brain stimulation
Increase dopamine levels: Levodopa
substantia nigra damage
Bowel Irregulation
bowel muscle rigidity
Bowel slowness
extranigral lesions
Intestinal Pseudo-Obstruction (IPO)
treated with Magnesium oxide
result of Lewy Body in myenteric plexus
Treatment
Endocrine Dysfunction
loss of dopamine
disorganized Basal Ganglia
Pineal Gland dysruption
decreased melatonin
Treatment
Increase dopamine levels
Urinary Dysfunction
voiding symptoms
loss of micturition reflex
storage symptoms
Nocturia
treatment
Dopaminergic drugs
Cholinergic drugs
serotonergic drugs
caused by degeneration of neurons in mesencephalon