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Narcotic Analgesics - Coggle Diagram
Narcotic Analgesics
Opioid Receptors
Receptor Type
Gi GPCRs
Effect
Activation of K+ channels / Inhibition of Ca2+ channels
Hyperpolarisation of neurons
Substance P not released
Subtypes
μ
δ
κ
Location
High concentrations in Dorsal Horn of Spinal Cord
Opioids
Endogenous
Endorphins
Enkephalins
Dynorphins
Endomorphins
Synthetic
Morphine
Codeine
Heroin
Methadone
Remifentanil
Effects
Therapeutic
Endogenous analgesia (no pain felt)
Side Effects
Respiratory depression :arrow_down:
Nausea :nauseated_face:
Definition
Addictive drugs that effect mood and behaviour
MOA
Activation of Opiod receptors
Hyperpolarisation of neuron
Inhibits nociceptive signalling by blocking neurotransmission in 2nd order neurons
Inhibition of release of Substance P
Blocks neurotransmission of pain along ascending pathways