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Hepatic cirrhosis - Coggle Diagram

- - - - Consists of changes in genetic and phenotypic expression that make cells sensitive to cytokines and other local stimuli.
    - - Autocrine and paracrine stimulation that consumes sinusoidal endothelial cells, Kupffer cells, hepatocytes, platelets, and leukocytes. Rapid remodeling of the extracellular matrix, amplification of the activated phenotype through growth factor expression.
  - - - Fibrosis describes the encapsulation or replacement of injured tissue by a collagenous scar.