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Anti-Viral Drugs - Coggle Diagram

- - - - Bind to & block the function of the NS5A Protein, prevents RNA replication & assembly of the virus
    - - Asvir
- - - - Acyclovir
        
        Mechanism
        
        Activated by viral thymidine kinase which adds the first phosphate
        
        Most efficient chain terminator or competitive inhibitor. Has a short t1/2
    - - Cidifovir
        
        used on herpesviruses that have 1st developed resistance to acyclovir class of drugs
        
        Does not need viral thymidine kinase to be activated!
        
        also works against other DNA viruses
    - - Mechanism
        
        Binds phosphate binding site of the polymerase blocking nucleotide binding (Herpes, HIV-salvage therapy)
      - Side effects: Nephrotoxicity
      - A non-nucleotide analog Used after acyclovir fails
    - - Mechanism
        
        NS5B Polymerase Inhibitors, block replication of viral RNA
  - - - HBV: Hepadnavirus & HIV: retrovirus
        
        Suffix = ine
        
        Lamivudine, Tenofovir, & Entecavir are effective for both!
    - - Activated by cellular phosphorylation
      - Bind to a pocket in the reverse transcriptase distal to the active site & prevent reverse transcription
- - - - Prevents polyprotein cleavage & stops viral replication
      - HCV
    - - HIV