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Systemic Lupus Erythematosus - Coggle Diagram

- - - - Multi-system involvement
    - - Sustains inflammation
  - - - Target self-antigens
    - - Uncontrolled immune response
    - - Activates complement
        
        Inflammation & Tissue Damage
- - - - Lupus nephritis
        
        Proteinuria, hematuria, renal failure
    - - Pericarditis, myocarditis, atherosclerosis
    - - Pleuritis, interstitial lung disease, pulmonary hypertension
    - - Malar rash (butterfly rash), discoid lesions, photosensitivity
    - - Symmetric polyarthritis, joint pain
    - - Seizures, cognitive dysfunction, psychosis
    - - Anemia, leukopenia, thrombocytopenia
- - - - Increased risk of cardiovascular disease
  - - - Chronic kidney disease (CKD)
      - End-stage renal disease (ESRD)
  - - - Increased clotting risk (thrombosis)
  - - - Reduced lung function, pulmonary hypertension
- - - - Control acute inflammation
    - - Key drug for reducing disease flares
    - - Reduces autoantibody production
    - - Manage arthritis and musculoskeletal pain
  - - - Prevent thrombosis in antiphospholipid syndrome
    - - Manage neuropsychiatric symptoms
    - - Preserve renal function in lupus nephritis
  - - - Smoking cessation
        
        Reduces cardiovascular risk
      - Sun Protection
        
        Prevents UV-induced flares
      - Regular Exercise
        
        Prevents muscle weakness, reduces fatigue
      - Diet & Hypertension Management
        
        Protects kidney function