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Erythron - Coggle Diagram

- - - - SCF (stem cell factor)
      - CFU (colony forming units)
      - GM-CSF (granulocyte-macrophage-CSF)
      - IL1, IL2, IL3, IL4, IL5, IL6, IL7, EPO, TPO (macrophage & lymphocytes)
    - - Blood supply
      - nutrient
      - O2
    - - Pluripotent
        
        Capable of differentiation into clone or mixed of cell under influence of growth factor
      - Committed
        
        Differentiate into one cell type under specific cytokine
  - - - Spleen, Liver, LN
- - - - -RBC produce in BM is 4d -EPO stimulated by renal hypoxia, influence Hb synthesis and release young RBC
    - - Represent balance between production in the BM and destruction by macrophages in spleen. Breakdown into iron and heme
      - Pig = 60d, Cat = 70d, cow and horse = 155d, Dog and goat = 120d, Sheep = 140-155d
    - - Stimulator: -Erythropoietin (EPO): The main hormone that stimulates red blood cell production.
        
        Androgens (Steroids): Increase EPO production and improve red blood cell formation. - Thyroxine (Thyroid Hormone): Helps produce EPO; low levels can reduce hemoglobin synthesis. -Growth Hormone (GH): Deficiency leads to poor erythropoiesis (blood cell formation). - Prostaglandins (PGE₂): Work with EPO, especially in low oxygen (hypoxia) conditions.
      - Modulator (CSF): - Help regulate blood cell production. - TNF (Tumor Necrosis Factor), IL-1, Interferon
      - Suppressor: - EPO Inhibition Factors: 1) PGE₂ and IL-1 reduce EPO production. 2) PGE₂ also suppresses CSF-GM (which stimulates white blood cell production).