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COLON CANCER - Coggle Diagram
COLON CANCER
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Clinical presentation
Changes in bowel habits (diarrhea, constipation)
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Pathogenesis
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Carcinoma → Metastasis
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Pro-angiogenic factors (VEGF, MMPs) → Promote new blood vessel formation, allowing tumor growth and nutrient supply.
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Metastasis → Tumor cells enter the bloodstream or lymphatic system, spreading to distant organs such as the liver and lungs.
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Investigations
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CBC: Microcytic hypochromic anemia, Leukocytosis
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Risk Factors
Genetic Syndromes: Familial Adenomatous Polyposis, Lynch Syndrome
Diet: High red/processed meat intake, Low fiber diet, High-fat, low-vegetable diet
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