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Cirrhosis Pathophysiology - Coggle Diagram
Cirrhosis Pathophysiology
1 causes
Chronic hepatitis
: B & C
Alcoholic liver disease
Autoimmune hepatitis
Metabolic disorders
: Wilson’s disease, hemochromatosis
Biliary disease
: Primary biliary cholangitis, primary sclerosis cholangitis
Pathologies
Chronic Hepatocyte injury
repeated liver cell damage (viral, toxic & metabolic)
Inflammation & Fibrosis Progression
Persistent inflammation → cytokine release
Activation of hepatic stellate cells → excessive collagen deposition
Formation of regenerative nodules
Disorganized liver architecture → impaired function
Increased Portal Pressure → Portal Hypertension
Clinical features
Early stages (Compensated Cirrhosis)
Asymptomatic or mild symptoms (fatigue, weight loss, RUQ pain)
Late stages (Decompensated Cirrhosis)
Jaundice: Hyperbilirubinemia (yellow skin/eyes)
Hepatic Encephalopathy: Confusion due to toxin buildup (ammonia)
Coagulopathy: Easy bruising/bleeding (due to ↓ clotting factors)
Splenomegaly & Anemia: Due to hypersplenism
Complications
Portal Hypertension → Esophageal varices (risk of GI bleeding)
Hepatocellular Carcinoma (HCC) → Increased risk due to chronic liver damage
Liver Failure → Multi-organ dysfunction, need for liver transplant
Spontaneous Bacterial Peritonitis